Database : HANSEN
Search on : TESTES DE SENSIBILIDADE MICROBIANA/METODOS [Subject descriptor]
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Id:18390
Author:Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K
Title:Drug resistant-Mycobacterium leprae- results of mouse footpad studies from a laboratory in South India ..-
Source:s.l; s.n; 2002. 12 p. tab.
Abstract:Out of 265 biopsies of leprosy patients received at the Experimental Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae using the mouse footpad technique, 49 showed resistant strains of M. leprae to varying concentration of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resitance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistent strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emplasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community (AU).
Descriptors:MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/isol
MYCOBACTERIUM LEPRAE/metab
MYCOBACTERIUM LEPRAE/patogen
MYCOBACTERIUM LEPRAE/ultraest
RESISTÊNCIA A DROGAS
DAPSONA/uso terap
CLOFAZIMINA/uso terap
RIFAMPINA/uso terap
TESTES DE SENSIBILIDADE MICROBIANA/métodos
TESTES DE SENSIBILIDADE MICROBIANA/vet
HANSENIASE/clas
 HANSENIASE/compl
 HANSENIASE/quimioter
 HANSENIASE/imunol
 HANSENIASE/microbiol
 HANSENIASE/patol
 OFLOXACINO/uso terap
 MINOCICLINA/uso terap
Limits:HUMANO
Location:BR191.1; 09299/s


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Id:18385
Author:Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong
Title:Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice ..-
Source:s.l; s.n; 2000. 3 p. tab.
Abstract:Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP. Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slighthy more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae (AU).
Descriptors:HANSENIASE/quimioter
HANSENOSTATICOS/admin
HANSENOSTATICOS/farmacol
HANSENOSTATICOS/farmacocin
HANSENOSTATICOS/uso terap
MYCOBACTERIUM LEPRAE
TESTES DE SENSIBILIDADE MICROBIANA/métodos
DROGAS EM INVESTIGACAO/admin
DROGAS EM INVESTIGACAO/anal
DROGAS EM INVESTIGACAO/uso terap
BACTERICIDAS
 QUIMIOTERAPIA COMBINADA
 MYCOBACTERIUM LEPRAE/metab
 MYCOBACTERIUM LEPRAE/fisiol
 DAPSONA/uso terap
 RIFAMPINA/uso terap
 CLOFAZIMINA/uso terap
 OFLOXACINO/uso terap
 MINOCICLINA/uso terap
 CLARITROMICINA/uso terap
Limits:ESTUDO COMPARATIVO
Location:BR191.1; 09311/s


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Id:18225
Author:Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K
Title:Drug resistant-Mycobacterium leprae--results of mouse footpad studies from a laboratory in south India ..-
Source:s.l; s.n; 2002. 12 p. tab.
Abstract:Out of 265 biopsies of leprosy patients received at the Experimental Pathology Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae, using the mouse footpad technique, 49 showed resistant strains of M leprae to varying concentrations of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resistance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistant strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emphasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community. (AU).
Descriptors:Clofazimina/PD
Dapsona/PD
Farmacorresistência Bacteriana
Farmacorresistência Bacteriana Múltipla
Índia
Hansenostáticos/*PD
Hanseníase/*DT/MI
Camundongos
Camundongos Endogâmicos CBA
Testes de Sensibilidade Microbiana
Mycobacterium leprae/*DE
Rifampina/PD
Limits:HUMANO
ANIMAL
MASCULINO
FEMININO
Location:BR191.1; 09179/S


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Id:15629
Author:Salem, Isam Ismail; Steffan, Gerhard; Düzgünes, Nejat
Title:Efficacy of clofazimine - modified cyclodextrin against Mycobacterium avium complex in human macrophages ..-
Source:s.l; s.n; 2003. 10 p. graf.
Abstract:Clofazimine, a water insoluble substituted iminophenazine derivative with anti-mycobacterial and anti-inflammatory activity, is recommended by the WHO for the treatment of leprosy. It is also active against disseminated Mycobacterium avium complex (MAC) disease in HIV-infected patients. Recently, we achieved a 4000-fold increase of clofazimine water solubility using a novel modified clofazimine-cyclodextrin complex synthesized and patented by our group [Wasserlösliche, Iminiophenazinderivate enthaltende pharmazeutische Zusammensetzungen, deren Herstellung und Verwendung, German Patent, DE19814814C2]. In this paper we examine the activity of this complex against MAC in human macrophages, and evaluate its cytotoxicity. MAC-infected macrophages were treated for 24h with free or complexed clofazimine. The in vitro minimum inhibitory concentrations of both free and complexed clofazimine were 0.1 microg/ml. Free and complexed clofazimine inhibited the growth of MAC inside macrophages to a similar extent, while modified cyclodextrin alone had no observable effects on MAC or macrophages. Complexed clofazimine was not toxic to cells at concentrations effective against MAC. The TD(50) of the modified cyclodextrin in THP-1 cell line was 297 microg/ml. (AU).
Descriptors:ANTIINFECCIOSOS/quim
ANTIINFECCIOSOS/farmacol
ANTIINFECCIOSOS/tox
CELULAS CULTIVADAS
CLOFAZIMINA/quim
CLOFAZIMINA/farmacol
CLOFAZIMINA/tox
MACROFAGOS/ef drogas
TESTES DE SENSIBILIDADE MICROBIANA
COMPLEXO MYCOBACTERIUM AVIUM/ef drogas
ESTEROIS/quim
ACIDO SUCCINICO
Limits:ESTUDO COMPARATIVO
HUMANO
ANIMAL
CAMUNDONGOS
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 09082/s


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Id:13945
Author:Salem, Isam Ismail; Steffan, Gerhard; Düzgünes, Nejat
Title:Efficacy of clofazimine - modified cyclodextrin against Mycobacterium avium complex in human macrophages ..-
Source:s.l; s.n; 2003. 10 p. graf.
Abstract:Clofazimine, a water insoluble substituted iminophenazine derivative with anti-mycobacterial and anti-inflammatory activity, is recommended by the WHO for the treatment of leprosy. It is also active against disseminated Mycobacterium avium complex (MAC) disease in HIV-infected patients. Recently, we achieved a 4000-fold increase of clofazimine water solubility using a novel modified clofazimine-cyclodextrin complex synthesized and patented by our group [Wasserlösliche, Iminiophenazinderivate enthaltende pharmazeutische Zusammensetzungen, deren Herstellung und Verwendung, German Patent, DE19814814C2]. In this paper we examine the activity of this complex against MAC in human macrophages, and evaluate its cytotoxicity. MAC-infected macrophages were treated for 24h with free or complexed clofazimine. The in vitro minimum inhibitory concentrations of both free and complexed clofazimine were 0.1 microg/ml. Free and complexed clofazimine inhibited the growth of MAC inside macrophages to a similar extent, while modified cyclodextrin alone had no observable effects on MAC or macrophages. Complexed clofazimine was not toxic to cells at concentrations effective against MAC. The TD(50) of the modified cyclodextrin in THP-1 cell line was 297 microg/ml. (AU).
Descriptors:ANTIINFECCIOSOS/quim
ANTIINFECCIOSOS/farmacol
ANTIINFECCIOSOS/tox
CLOFAZIMINA/quim
CLOFAZIMINA/farmacol
CLOFAZIMINA/tox
CELULAS CULTIVADAS
MACROFAGOS/ef drogas
MACROFAGOS/microbiol
TESTES DE SENSIBILIDADE MICROBIANA
COMPLEXO MYCOBACTERIUM AVIUM/ef drogas
ESTEROIS/quim
ACIDO SUCCINICO/quim
Limits:ESTUDO COMPARATIVO
HUMANO
ANIMAL
CAMUNDONGOS
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 09082/s


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Id:13618
Author:Reichart, P. A; Samaranayake, L. P; Samaranayake, Y. H; Grote, M; Pow, E; Cheung, B
Title:High oral prevalence of Candida krusei in leprosy patients in northern Thailand ..-
Source:s.l; s.n; Dec.2002. 7 p. tab, graf.
Abstract:Although Candida albicans is the most common human yeast pathogen, other Candida species such as C. krusei are now recognized as emerging agents, especially in patients with human immunodeficiency virus (HIV) disease. C. krusei is inherently resistant to the widely used triazole antifungal fluconazole and poses therapeutic problems, especially in systemic candidiasis. In a surveillance study of leprosy patients (with arrested or burnt-out disease) in a leprosarium in northern Thailand, we found a rate of oral carriage of C. krusei (36 per cent) significantly (P smaller 0.05) higher than that for a healthy control group (10 per cent). Among the Candida-positive patients, 16 of 35 (46 per cent) carried C. krusei, while C. albicans was the second most common isolate (12 of 35 patients; 34 per cent). The corresponding figures for the control group were 2 of 13 (15 per cent) and 6 of 13 (46 per cent), respectively. Studies of the antifungal resistance of the C. krusei isolates from patients indicated that all except one of the isolates were resistant to fluconazole, two isolates were resistant to ketoconazole, and all isolates were sensitive to amphotericin B. Evaluation of their genetic profiles by randomly amplified polymorphic DNA analysis with three different primers and subsequent analysis of the gel profiles by computerized cluster-derived dendrograms revealed that the C. krusei isolates from patients belonged to 10 disparate clusters, despite the origin from a single locale. These nascent findings indicate an alarmingly high prevalence of a Candida species resistant to a widely used antifungal in a part of the world where HIV disease is endemic. (AU).
Descriptors:ANTIMICOTICOS/farmacol
CANDIDA/clas
CANDIDA/ef drogas
CANDIDA/genet
CANDIDA/isol
CANDIDIASE BUCAL/compl
CANDIDIASE BUCAL/epidemiol
CANDIDIASE BUCAL/microbiol
PORTADOR/epidemiol
PORTADOR/microbiol
Resistência Fúngica a Múltiplas Drogas
HANSENIASE/compl
TESTES DE SENSIBILIDADE MICROBIANA
BOCA/microbiol
PREVALÊNCIA
TECNICA DE AMPLIFICACAO AO ACASO DE DNA POLIMORFICO
TAILÂNDIA/epidemiol
Limits:HUMANO
MASCULINO
FEMININO
MEIA-IDADE
IDOSO
IDOSO DE 80 ANOS OU MAIS
Location:BR191.1; 09003/s


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Id:13262
Author:Goodwin, C. S; Wood, M. J
Title:Bacteria isolated from plantar ulcers of Ethiopian leprosy patients, with the antibacterial drug sensitivities of the isolates ..-
Source:s.l; s.n; 1970. 6 p. tab.
Abstract:Bacteriological sampling of grossly infected or chronic plantar ulcers was perfomed in 39 untreated patients with leprosy and in 22 patients who had received antibiotic treatment. Samples were cultured aerobically and anaerobically, and films of pus were stained by Gram´s method. Stained films gave little indication of the type of infecting pathogen, except when Gram-positive cocci alone were seen. From the ulcers of patients untreated with antibiotics anaerobic streptococci were isolated more frequently than any other organism, and and this may be an original observation. Of the 8 Staphylococcus aureus isolates 5 were penicillin sensitive. A renge of Gram-negative bacteria, but no Clostridia, were isolated. From the ulcers of patients who had received antibiotics penicillin-resistant Staph. aureus was most frequently isolated. Some Gram-positive bacteria resistant to tetracycline were sensitive to doxycycline.(AU).
Descriptors:ANTIBIOTICOS/uso terap
BACTERIAS/isol
DERMATOSES DO PE/quimioter
HANSENIASE/compl
TESTES DE SENSIBILIDADE MICROBIANA
PENICILINAS/uso terap
ULCERA CUTÂNEA/quimioter
ULCERA CUTÂNEA/microbiol
STAPHYLOCOCCUS/isol
STREPTOCOCCUS/isol
Limits:HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
ADOLESCENTE
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00740/s


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Id:13258
Author:Heifets, Leonid B
Title:Synergistic effect of rifampin, streptomycin, ethionamide, and ethambutol on Mycobacterium intracellulare ..-
Source:s.l; s.n; jan. 1982. 6 p. tab, graf.
Abstract:A method of quantitative estimation to determine the interaction of antituberculosis drugs is suggested. The design of experiments, performed on 7H11 agar plates, is adjusted to the following statistical treatment by combined use of probit analysis and isobologram methods. By plotting the values reflecting the inhibition of 75% of the bacterial population (ED75) with their confidence limits on the isobologram, it was found that the clearest results proving synergism between the drugs could be obtained. Six 2-drug combinations and 6 3-drug combinations were tested against strains of Mycobacterium intracellulare (serovar 8), and a synergistic effect was demonstrated in most of them. These were various combinations of rifampin, streptomycin, ethambutol, and ethionamide. The application of probit analysis to the data derived from testing single drugs can provide a quantitative estimation of the actual drug resistance of the M. intracellulare strains.(AU).
Descriptors:SINERGISMO DE DROGAS
TESTES DE SENSIBILIDADE MICROBIANA
MICOBACTERIAS ATIPICAS/ef drogas
MYCOBACTERIUM/ef drogas
ETAMBUTOL/farmacol
ETIONAMIDA/farmacol
RIFAMPINA/farmacol
ESTREPTOMICINA/farmacol
Limits:SUPPORT, NON-U.S. GOV'T
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00960/s


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Id:13234
Author:Chatterjee, B. D; Chakraborti, C. K; Chaudhuri, S
Title:Microflora in the trophic ulcers of the foot in leprosy ..-
Source:s.l; s.n; oct. 1985. 4 p. tab.
Abstract:Out of 25 cases of trophic ulcers of the foot, 10 (40%) were both aerobic and anaerobic, 14 (56%) only aerobic and one (4%) showed no growth of bacteria. With the exception of two cases (8%) in the aerobic group, all others showed mixed infections. A wide range of bacteria is reported. Topical application of gentamicin and chloramphenicol is recommended, based on the results of in vitro sensitivity.(AU).
Descriptors:DOENCAS DO PE/microbiol
HANSENIASE/microbiol
TESTES DE SENSIBILIDADE MICROBIANA
ULCERA CUTÂNEA/microbiol
BACTERIAS ANAEROBIAS/ef drogas
BACTERIAS ANAEROBIAS/isol
BACTERIAS AEROBIAS/ef drogas
BACTERIAS AEROBIAS/isol
Limits:HUMANO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 02156/s


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Id:11750
Author:Cambau, Emmanuelle; Bonnafous, Pascale; Perani, Evelyne; Sougkoff, Wladimir; Ji, Baohong; Jarlier, Vicent
Title:Molecular detection of rifampin and ofloxacin resistance for patients Who experience relapse of multibacillary leprosy ..-
Source:s.l; s.n; 2002. 7 p. tab.
Descriptors:DNA BACTERIANO
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
OFLOXACINA
RECIDIVA
RIFAMPINA
ANTIBIOTICOS ANTITUBERCULOSE
DNA TOPOISOMERASE (ATP-HIDROLISANTE)
DNA TOPOISOMERASE (ATP-HIDROLISANTE)
MODELOS ANIMAIS DE DOENÇAS
TESTES DE SENSIBILIDADE MICROBIANA
HANSENIASE
MUTAÇAO
PROTEINAS DE PLANTAS
PROTEINAS DE PLANTAS
Location:BR191.1; 08526/s; BR191.1; 08659/s


  11 / 19 HANSEN  
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Id:11469
Author:darricarrere T, Rafael; Ojeda Sch, Alicia
Title:Aioslamiento de corynebacterium grupo "JK" (CJK) en pacientes inmunocomprometidos ?-
Source:s.l; s.n; 1987. 6 p. tab.
Descriptors:CORYNEBACTERIUM
HOSPEDEIRO IMUNOCOMPROMETIDO
LUPUS ERITEMATOSO SISTEMICO
HANSENIASE TUBERCULOIDE
LEISHMANIOSE MUCOCUTANEA
TESTES DE SENSIBILIDADE MICROBIANA
RETO
Location:BR191.1; 08347/s


  12 / 19 HANSEN  
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Id:11445
Author:Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong
Title:Bactericidal activities of HMR 3647, monofloxacin, and rifapentine against mycobacterium leprae in mice ..-
Source:s.l; s.n; 2000. 3 p. tab.
Descriptors:AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA
AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA
ANTIBIOTICOS MACROLIDIOS
ANTIBIOTICOS MACROLIDIOS

LEPROSTATICOS
LEPROSTATICOS
HANSENIASE
HANSENIASE
CAMUNDONGOS
TESTES DE SENSIBILIDADE MICROBIANA
MYCOBACTERIUM LEPRAE
RIFAMPINA
RIFAMPINA
RIFAMPINA
Limits:ESTUDO COMPARATIVO
ANIMAL
Location:BR191.1; 08327/s


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Id:10148
Author:Dhople, Arvind M; Williams, Sharon L
Title:The activity of rifabutin against Mycobacterium leprae in armadillos ..-
Source:s.l; s.n; 1997. 5 p. tab.
Descriptors:TATUS
MODELOS ANIMAIS DE DOENÇAS
LEPROSTATICOS
LEPROSTATICOS
LEPROSTATICOS
HANSENIASE
HANSENIASE
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS BALB C
TESTES DE SENSIBILIDADE MICROBIANA
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
RIFABUTINA
RIFABUTINA
RIFABUTINA
Limits:ANIMAL
Location:BR191.1; 07112/s


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Id:9907
Author:Franzblau, Scott G; Chan, Gertrude P; Garcia-Ignacio, Bernadette G; Chavez, Virginia E; Livelo, Jocelyn B; Jimenez, Claribel L; Parrilla, Manuela Luiza R; Calvo, Rally F; Williams, Diana L; Gillis, Thomas P
Title:Clinical trial of fusidic acid for lepromatous leprosy ..-
Source:s.l; s.n; 1994. 4 p. tab.
Descriptors:ADOLESCENCIA
CRIANÇA


ACIDO FUSIDICO
GLICOLIPIDIOS
HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
CAMUNDONGOS
TESTES DE SENSIBILIDADE MICROBIANA
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
REAÇAO EM CADEIA POR POLIMERASE
PELE
ESPIROMETRIA
FATORES DE TEMPO
Limits:ANIMAL
Location:BR191.1; 06884/s


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Id:9634
Author:Jamil, S; Keer, J. T; Lucas, S. B; Dockrell, H. M; Chiang, T. J; Hussain, R; Stoker, N. G
Title:Use of polymerase chain reaction to assess efficacy of leprosy chemotherapy ..-
Source:s.l; s.n; 1993. 5 p. tab.
Descriptors:SEQUENCIA DE BASES
DNA BACTERIANO
LEPROSTATICOS
LEPROSTATICOS
HANSENIASE
HANSENIASE
TESTES DE SENSIBILIDADE MICROBIANA
DADOS DE SEQUENCIA MOLECULAR
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
REAÇAO EM CADEIA POR POLIMERASE
Location:BR191.1; 06558/s


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Id:9539
Author:Tomioka, H; Sato, K; Saito, H
Title:Comparative in vitro and in vivo activity of fleroxacin and ofloxacin against various mycobacteria ..-
Source:s.l; s.n; 1991. 5 p. tab.
Descriptors:MODELOS ANIMAIS DE DOENÇAS
FLEROXACINA
FLEROXACINA
HANSENIASE
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS BALB C
TESTES DE SENSIBILIDADE MICROBIANA
MYCOBACTERIUM
MICOBACTERIOSE ATIPICA
MYCOBACTERIUM AVIUM
MYCOBACTERIUM TUBERCULOSIS
OFLOXACINA
OFLOXACINA
Location:BR191.1; 06265/s


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Id:9128
Author:Mocellin, Marcos; Repka, Joao; Stahlke, Luciana Gabardo; Catani, Guilherme S; Stahlke, Paulo S. D. B; Yosida, Luiz; Cabrera, Pablo F. A
Title:Avaliacao da microbiota bacteriana nasal de hansenianos Evaluation of the nasal bacterial microbiota of bearers of Hansen's disease-
Source:s.l; s.n; 1998. 6 p. ilus, tab.
Descriptors:MUCOSA NASAL
RESISTENCIA MICROBIANA A DROGAS
HANSENIASE
RIFAMPINA
CLOFAZIMINA
DAPSONA
ANTIBIOTICOS COMBINADOS
TESTES DE SENSIBILIDADE MICROBIANA
GRUPOS CONTROLE
PROTEUS MIRABILIS
ESCHERICHIA COLI
PSEUDOMONAS AERUGINOSA
OXACILINA
Location:BR191.1; 06086/s


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Id:8369
Author:Franzblau, Scott G; Hastings, Robert C
Title:Rapid in vitro metabolic screen for antileprosy compounds ..-
Source:s.l; s.n; 1987. 4 p. tab, graf.
Descriptors:HANSENIASE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
ADENOSINA TRIFOSFATO
LEPROSTATICOS
TESTES DE SENSIBILIDADE MICROBIANA
Location:BR191.1; 02414/s


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Id:3809
Author:David, Hugo L; Clavel, Sabine; Clement, Françoise; Moniz-Pereira, José
Title:Effects of antituberculosis and antileprosy drugs on mycobacteriophage D29 growth ..-
Source:s.l; s.n; 1980. 2 p. graf, tab.
Descriptors:MYCOBACTERIUM
ANTITUBERCULOSOS
ANTIVIRAIS
LEPROSTATICOS
TESTES DE SENSIBILIDADE MICROBIANA
MICOBACTERIOFAGOS
MICOBACTERIOFAGOS
Location:BR191.1; 02649/s



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